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Functional analysis of soluble guanylyl cyclase regulation in photoreceptor cells
Reference
S11816
Principal Investigator / Supervisor
Professor Maurice Elphick
Co-Investigators /
Co-Supervisors
Institution
Queen Mary University of London
Department
Sch of Biological and Chemical Sciences
Funding type
Research
Value (£)
174,344
Status
Completed
Type
Research Grant
Start date
01/03/2000
End date
01/03/2003
Duration
36 months
Abstract
The enzyme soluble guanylyl cyclase (SGC) mediates physiological effects of the signalling molecule nitric oxide (NO). Drugs that interact with this pathway are used for treatment of several clinical conditions (e.g. angina). Little is known, however, about the role of other biochemical factors (e.g. carbon monoxide (CO), intracellular Ca2+, kinases, phosphodiesterases) in regulating SGC activity in vivo. To address this issue, we will analyse a model invertebrate preparation, the locust eye, where light causes Ca2+-dependent inhibition of SGC activity (Jones and Elphick, 1999). The main aims of the project will be: 1. to determine how light affects the expression and activity of SGC in locust photoreceptor cells and, 2. to examine the role of NO and CO in mediating in vivo activation of SGC in photoreceptor cells.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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