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Agouti related protein is produced in the adrenal cortex as an autocrine antagonist of ACTH receptor activity

Reference	S11814
Principal Investigator / Supervisor	Professor Philip Lowry
Co-Investigators / Co-Supervisors	Dr Richard Gladwell, Dr Esther Gail Hutchinson
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	140,310
Status	Completed
Type	Research Grant
Start date	01/10/1999
End date	01/10/2002
Duration	36 months

Abstract

Agouti related protein (AgRP), a new antagonist of the melanocortin receptors (MC), has been reported to be expressed in the brain and adrenal medulla. It would appear however that the medulla was mistaken for the inner zone of the cortex, a conclusion born out by our observations which indicate that its expression increases throughout the glucocortcoid sector of the rat adrenal cortex both after fasting and during compensatory growth following unilateral adrenalectomy. Its local production may therefore act as an autocrine antagonist or a receptor modifying protein at the ACTH receptors on adrenocortical cells to allow other POMC peptides to express their activity locally or the increased ACTH free to activate lipolysis at the adipocyte.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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