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The role of CNS purinoceptors in the control of respiration: a novel mechanism for chemoreception
Reference
S11806
Principal Investigator / Supervisor
Professor Kenneth Spyer
Co-Investigators /
Co-Supervisors
Dr Brian Frederick King
,
Dr Teresa Thomas
Institution
University College London
Department
Physiology
Funding type
Research
Value (£)
285,512
Status
Completed
Type
Research Grant
Start date
01/03/2000
End date
01/03/2003
Duration
36 months
Abstract
The study will use in vivo electrophysiology, immunocytochemistry and recombinant technology to determine the molecular mechanism underlying the CNS evoked respiratory response to changes in arterial CO2 levels. It will test the hypothesis that 2PX purinoreceptors localised on respiratory neurones of rostroventrolateral medulla (RVL) mediate the changes in ventilation that follow changes in arterial CO2 levels. Using immunocytochemistry, we will identify the classes of P2X receptors localised on individual respiratory neurones of the RVL, and with recombinant technology we will address the pH sensitivity of these P2X receptors. In in vivo studies agonists and antagonists of P2X receptors will be used to determine the actions of these receptors in mediating the respiratory responses to changes in inspired CO2.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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