Award details

The metabolic regulation of folliculogenesis and ovulation

Reference	S11749
Principal Investigator / Supervisor	Professor Rex John Scaramuzzi
Co-Investigators / Co-Supervisors	Professor David Baird, Professor Bruce Campbell
Institution	Royal Veterinary College
Department	Veterinary Basic Sciences - London
Funding type	Research
Value (£)	177,884
Status	Completed
Type	Research Grant
Start date	01/05/2000
End date	01/05/2003
Duration	36 months

Abstract

Leptin, a newly discovered hormone, produced by adipocytes, acts on the hypothalamus to regulate food intake and obesity. It acts via receptors which are also present in the ovary. This suggests a role for leptin in the ovary especially since food intake and obesity are linked to ovarian function. This project will determine the role of leptin in the regulation of ovarian function. First: the in vitro effect of leptin on steroid leptin will be studied in cultured ovarian (granulosa and theca) cells. Second: the in vivo effect of leptin will be examined in the sheep ovarian autotransplant model to determine the role of leptin in the nutritional regulated folliculogenesis. The information will be beneficial to understanding nutritional influences on reproduction in human medicine and livestock production. The project involves the complimentary expertise of Prof. Scaramuzzi (ruminant reproduction and nutrition) Prof. Baird (human reproduction and ovarian autotransplantation) and Dr Campbell (granulosa and theca cell culture, ovarian ultrasound). This project will determine the role of leptin as a modulator of nutritional effects on the ovary and may provide a physiological basis for the commercial utilisation of leptin agonists and antagonists to improve reproduction in clinical obesity and malnutrition.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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