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Critical determinants of somatic muscle excitability in the model genetic organism Caenorhabditis elegans
Reference
S11707
Principal Investigator / Supervisor
Professor Lindy Holden-Dye
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
162,348
Status
Completed
Type
Research Grant
Start date
01/05/1999
End date
30/09/2002
Duration
41 months
Abstract
The genome of C. elegans will be completely sequenced by the end of 1998 and for the first time we will be able to predict the entire complement of ion channels that control excitable cells. To exploit this information, we propose to make whole cell patch clamp recordings from motoneurones and muscle in order to identify genes that are critical to determining the excitability of the somatic muscle cells. This will provide an important basis for the analysis of mutants and, by gene deletion and substitution, the conserved role of these channels in mammals.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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