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Mutational analyses of the equine arteritis virus proteins GL and M; effects upon virus replication and pathogenesis

Reference	S11619
Principal Investigator / Supervisor	Dr Nicholas Davis-Poynter
Co-Investigators / Co-Supervisors	Dr Barry McAleer
Institution	The Animal Health Trust
Department	Centre for Preventive Medicine
Funding type	Research
Value (£)	209,380
Status	Completed
Type	Research Grant
Start date	01/07/1999
End date	01/07/2003
Duration	48 months

Abstract

Equine arteritis virus (EAV) is a significant pathogen of horses which can induce abortion in pregnant mares and be persistently shed in the semen of infected stallions. The major virion proteins of EAV, GL and M, co-associate as a disulphide linked heterodimer, the functions of which may include virus binding and/or entry into susceptible cells. This study will seek to define the functions of GL and M and to determine regions of GL and M important for their interaction and function, using transient transfection in eukaryotic cells and the production of EAV recombinants via full length, infectious clones. The effects of GL and M mutations upon virus replication, dissemination and tissue tropism in vivo will also be studied.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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