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The relationship of genetic diversity and virulence in the pig pathogen Streptococcus suis

Reference	S11598
Principal Investigator / Supervisor	Professor Christopher Dowson
Co-Investigators / Co-Supervisors	Dr Adrian Whatmore
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	115,885
Status	Completed
Type	Research Grant
Start date	12/07/1999
End date	12/07/2001
Duration	24 months

Abstract

Streptococcus suis, an economically important pig pathogen, can cause a range of diseases or be carried asymptotically and, on occasion, causes human zoonoses. The biology and pathogenic mechanisms of S. suis are poorly understood. A population genetic analysis performed by multilocus sequence typing (MLST) will characterise the S. suis population structure, identify clonal groups associated with particular diseases and carriage, investigate the feasibility of typing systems based on MLST, examine the occurrence of capsular switching, and identify the basis of human zoonotic infection. Superimposed on this will be an analysis of allelic variation of putative virulence factors of S. suis allowing correlation of alleles to virulence. Finally subtractive hybridisation of avirulent from virulent isolates will be performed to identify the genetic basis of pathogenesis.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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