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An in vitro study of the determinants of vertebral compressive strength

Reference	S11548
Principal Investigator / Supervisor	Professor Michael Adams
Co-Investigators / Co-Supervisors	Dr Patricia Dolan, Professor Donal McNally, Professor Jonathan Tobias, Dr Glenn Wakley
Institution	University of Bristol
Department	Anatomy
Funding type	Research
Value (£)	176,392
Status	Completed
Type	Research Grant
Start date	01/01/2000
End date	01/02/2003
Duration	37 months

Abstract

The aim of the proposed research is to provide a scientific basis for the accurate prediction of human vertebral compressive strength. The compressive strength of 100 human spine specimens will be measured in vitro under physiologically-reasonable conditions, and compared with measurements of the following properties of the spines: vertebral body bone mass, micro-architecture and materials properties; stress distributions in the adjacent intervertebral disc; and apophyseal joint load-bearing. Multiple regression models will then be used to identify the major determinants of vertebral compressive strength. Potential medical applications include the identification of those who are most at risk of injury from heavy manual labour, or who would benefit most from treatments designed to reduce the risk of osteoporotic fracture.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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