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The immunobiology of prions during peripheral scrapie pathogenesis
Reference
S11538
Principal Investigator / Supervisor
Dr Raymond Bujdoso
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Veterinary Medicine
Funding type
Research
Value (£)
198,551
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
01/01/2003
Duration
36 months
Abstract
The development of transmissible spongiform encephalopathy (TSE) in the CNS following peripheral inoculation with prions is preceded by replication of infectious material in peripheral lymphoid tissue. The mechanism by which infectious material is transported to lymphoid tissue and the cell types within which it accumulates are undefined. The objective of this proposal is to investigate the interaction of prions with cells of the immune system during peripheral pathogenesis of scrapie in mice. The specific aims of the proposal are: (1) Determine the maturation/development of the spleen follicular dendritic cell network required for prion accumulation; (2) investigate the role of IgM and complement in the accumulation of prior material in spleen tissue; and (3) nvestigate the role of B cell subsets as cofactors in peripheral scrapie.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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