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Relationship between leukaemia inhibitory factor interleukins and protaglandins in uterine decidualisation
Reference
S11534
Principal Investigator / Supervisor
Professor Susan Kimber
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
197,512
Status
Completed
Type
Research Grant
Start date
11/10/1999
End date
11/10/2002
Duration
36 months
Abstract
The influence of cytokine (CK) leukaemia inhibitory factor (LIF) on decidualisation of murine endometrial stroma and its interactions with IL-1, TNF-, IL-11 and prostaglandins (PG) will be examined. We shall test the hypothesis (based on preliminary evidence) that LIF induces or suppresses decidualisation depending on the concentration of other local mediators (ILs and PGs). Maternal LIF is essential for implantation: embryos cannot implant in LIF-/- females and defective decidualisation is suggested. The cellular target(s) for and stromal response to LIF will be tested. We shall use an in vitro model of decidualisation as well as intact and LIF- /- females to examine how LIF, other Cks and PGs regulate decidualisation.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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