BBSRC Portfolio Analyser
Award details
Characterisation of an African swine fever virus encoded protein A238L which modulates the host immune response
Reference
S11531
Principal Investigator / Supervisor
Dr Linda Dixon
Co-Investigators /
Co-Supervisors
Dr Michael Parkhouse
Institution
The Pirbright Institute
Department
Div of Molecular Biology
Funding type
Research
Value (£)
195,801
Status
Completed
Type
Research Grant
Start date
01/11/1999
End date
15/11/2003
Duration
48 months
Abstract
We propose to study an African swine fever virus encoded protein, A238L, which has two defined functions that are likely to dramatically modulate the host immune response. We will study the mechanisms by which this proteins performs the dual functions of (a) inhibiting calcineurin phosphatase activity and (b) activation of NFkB dependent gene transcription. We will also study the effect of A238L expression on infected macrophage function by identifying host genes whose transcription is regulated by A238L.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search