Award details

Intraovarian roles of inhibins activins and follistatin in the chicken

Reference	S11514
Principal Investigator / Supervisor	Professor Philip Knight
Co-Investigators / Co-Supervisors	Dr Richard Gladwell
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	195,568
Status	Completed
Type	Research Grant
Start date	14/04/1999
End date	14/04/2002
Duration	36 months

Abstract

Inhibins, activins and follistatin are implicated as endocrine and local regulators of follicular development in mammals but little is known of their roles in birds. This project will use specific immunoassays to determine the quantitative distribution of inhibins A and B, activins A and AB throughout follicle development in the chicken. Expression of mRNAs for inhibin/activin subunits, follistatin, FSH/LH receptors and steroidogenic enzymes in granulosa and theca layers will be quantitated by in situ hybridisation. In vivo and vitro approaches will test whether inhibin-related peptides are involved in (i) generating the preovulatory LH/progesterone surge (ii) changing follicular responsiveness to LH/FSH (iii) recruitment of small follicles into the yolky hierarchy (iv) paracrine signalling within and between follicles to modulate theca/granulose cell differentiation.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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