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Molecular basis for the regulation of body weight in a seasonal animal model
Reference
S11504
Principal Investigator / Supervisor
Professor Fran Ebling
Co-Investigators /
Co-Supervisors
Dr Michael Hastings
Institution
University of Nottingham
Department
Sch of Biomedical Sciences
Funding type
Research
Value (£)
135,100
Status
Completed
Type
Research Grant
Start date
01/02/2000
End date
01/08/2002
Duration
30 months
Abstract
The aim is to understand the molecular mechanisms that regulate feed intake and body weight by investigating the control of profound annual cycles in these functions in the Siberian hamster. The project will use subtraction hybridisation to identify novel genes in the hypothalamus associated with the seasonally-induced obese and non-obese states. The function of candidate gene products will be tested using an in vivo protocol which will be validated through the study of the role of the melanocortin system in seasonal energy homeostasis. This system has been implicated in homeostatic regulation of feed intake and body weight in non-seasonal contexts, but its role in long-term body weight regulation is unknown. The project combines molecular biological expertise at The Rowett Institute with behavioural and physiological expertise in Cambridge.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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