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Morphology and synaptic connections of physiologically characterised baroreceptive neurones in the nucleus tractus solitarius of the rat

Reference	S11296
Principal Investigator / Supervisor	Professor Jim Deuchars
Co-Investigators / Co-Supervisors	Dr Julian Paton
Institution	University of Leeds
Department	Institute of Membrane & Systems Biology
Funding type	Research
Value (£)	161,396
Status	Completed
Type	Research Grant
Start date	04/10/1999
End date	04/10/2002
Duration	36 months

Abstract

This is a collaboration designed to physiologically and anatomically characterise the neurones in the nucleus tractus solitarius that receive input from baroreceptors and to identify the postsynaptic targets of these neurones. Arterial baroreceptors will be stimulated physiologically while recording from NTS neurones with patch pipettes filled with Neurobiotin in arterially perfused preparations of adult rat and mouse. Following intracellular labelling the medulla will be fixed and processed to reveal intracellularly labelled NTS neurones. Correlated light and electron microscopy will reveal the morphology, synaptic inputs and outputs of baroreceptive neurones. Potential postsynaptic targets of baroreceptive neurones will be labelled prior to the physiological experiment using retrograde tracing or with immunohistochemistry on sections after the experiment.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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