Award details

Synaptic transmission in the mammalian CNS and its modulation by general anaesthetics studied by two- photon microscopy

Reference	S11164
Principal Investigator / Supervisor	Professor Christopher Richards
Co-Investigators / Co-Supervisors	Professor Alistair Mathie
Institution	University College London
Department	University College London Department
Funding type	Research
Value (£)	344,725
Status	Completed
Type	Research Grant
Start date	12/02/1999
End date	12/09/2002
Duration	43 months

Abstract

The aim of this proposal is to use two-photon confocal microscopy to study events occurring at individual synapses within the CNS and their modulation by general anaesthetics. The proposed experiments will provide unambiguous answers to a number of key questions that cannot be resolved by other techniques: (i) do anaesthetics interfere with action potential propagation into the synaptic nerve terminal or do they affect the synaptic process directly? (ii) if they affect synaptic events, are their effects exerted via presynaptic or post-synaptic mechanisms? (iii) by providing answers to these questions the project will define the molecular targets at which anaesthetics act.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	BioImaging (BI) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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