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Investigating the impact of helminth infection on immune responses in a transgenic adoptive transfer system

Reference	S11031
Principal Investigator / Supervisor	Dr Catherine Lawrence
Co-Investigators / Co-Supervisors	Professor Eileen Devaney
Institution	University of Strathclyde
Department	Immunology
Funding type	Research
Value (£)	168,618
Status	Completed
Type	Research Grant
Start date	01/10/1999
End date	01/02/2003
Duration	40 months

Abstract

Helminth infections are amongst the most potent stimulators of the Th2-type of immune response and have been demonstrated to suppress responsiveness to both non-parasite antigens and other infectious agents in a non-specific manner. However, studies of these phenomena have been limited as a result of the inability to identify antigen-specific lymphocytes in a normal animal due to their extremely low frequency. In order to overcome this problem we will employ the recently developed technique of adoptively transferring transgenic lymphocytes into the physiological context of a normal animal. This approach will allow us to elucidate how helminth infections may affect the function and differentiation state of non-parasite-specific naive, primed or tolerant cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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