Award details

Immunological memory: An analysis of antigen specific CD4 memory T cells

Reference	S11008
Principal Investigator / Supervisor	Dr Eric Bell
Co-Investigators / Co-Supervisors	Professor Paul Garside
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	241,933
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	19/09/2003
Duration	57 months

Abstract

Protection against infectious disease by vaccination depends on the ability of the immune system to respond rapidly, often years later, to the infectious agent. We do not yet understand how immunological memory is organised at the cellular level. The present study will use a novel cell transfer system that is able to track definitely antigen-specific T and B lymphocytes in vivo. We will investigate CD4 memory T cells since these are critical to the establishment of immunological memory. The project will address fundamental issues including the life span of memory T cells, their migration paths, phenotype and ability to provide help for antibody production and whether their commitment to cytokine production is permanent. The project will provide important new data on the mechanisms underlying key features of the acquired immune response.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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