Award details

Physical conditions under which blood cells can adhere to the wall of vessels at high flow rate

Reference	S10953
Principal Investigator / Supervisor	Professor Gerard Nash
Co-Investigators / Co-Supervisors	Dr Timothy David, Dr Peter Walker
Institution	University of Birmingham
Department	Medical Sciences - Physiology
Funding type	Research
Value (£)	157,688
Status	Completed
Type	Research Grant
Start date	01/05/1999
End date	01/05/2002
Duration	36 months

Abstract

The molecular mechanisms by which leukocytes adhere to the vessel wall has been well- described but the physical constraints on adhesion are poorly understood. We hypothesise that adhesion of leukocytes in arteries with high flow rate can only occur in regions of flow separation and recirculation associated with surface irregularities, and is promoted by deposition of platelets. We will use computational fluid dynamics to predict patterns of flow and particle paths for blood cells in the region of a discontinuity in the wall of a vessel, and adapt existing flow-based adhesion assays to study adhesion interactions between blood cells and the vessel wall in such regions. Thus we aim to define at the physical and molecular level how white blood cells can be deposited along with platelets on the walls of vessels with high volumetric flow.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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