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Perinatal programming of the rat neuroendocrine and host defence systems: roles of glucocorticoids and lipocortin 1
Reference
S10905
Principal Investigator / Supervisor
Professor Julia Buckingham
Co-Investigators /
Co-Supervisors
Professor Susan Smith
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
300,817
Status
Completed
Type
Research Grant
Start date
01/10/1999
End date
01/10/2002
Duration
36 months
Abstract
Glucocortoids (GCs) play a key role in development, exerting irreversible influences on the growth, differentiation and activity of a variety of cells/tissues; they thus contribute to the perinatal programming of several physiological systems. Increasing evidence suggests that inappropriate exposure to GCs at critical stages of foetal/neonatal life may compromise health in later life but the molecular mechanisms effecting the detrimental actions of GCs are unknown. Our recent data have led us to propose that lipocortin 1 (a GC-inducible protein) is important in this regard; we now wish to test this hypothesis, using a multidisciplinary approach and focusing on the rat neuroendocrine and immune/inflammatory systems.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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