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The role of GABA in the superficial layers of the rat superior colliculus

Reference	S10901
Principal Investigator / Supervisor	Professor Bettina Platt
Co-Investigators / Co-Supervisors
Institution	University of Aberdeen
Department	Biomedical Sciences
Funding type	Research
Value (£)	164,687
Status	Completed
Type	Research Grant
Start date	15/08/1999
End date	15/08/2002
Duration	36 months

Abstract

This project concerns the properties of neurones in the superficial (visual) layers of the rat superior colliculus (SC) and the role of GABA and its receptors in SC physiology and development, with a special focus on the recently described excitatory action of GABA, presumably mediated via GABA-C receptors. This would be achieved by in vitro electrophysiological analysis of neuronal properties, combined with pharmacological characterisation of evoked currents and potentials. Neurones would also be morphologically identified to allow a correlation between physiology and cell type. Moreover, immunocytochemical techniques would be employed to study receptor profiles by means of confocal microscopy. Animals of different ages would be used to establish putative postnatal changes, dark-reared animals would show whether SC maturation is activity-dependent.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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