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Unit cell structure and intermolecular interactions in insect flight muscle in defined states
Reference
S10891
Principal Investigator / Supervisor
Professor John Squire
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
150,444
Status
Completed
Type
Research Grant
Start date
05/01/1999
End date
05/01/2002
Duration
36 months
Abstract
Muscular movement depends on the changing intermolecular interactions of actin molecules and myosin heads. These molecules are particularly well organised in insect flight muscles, where semi-crystalline low-angle X-ray diffraction patterns are obtained. We have already analysed and solved the structure of myosin filaments in relaxed insect flight muscle with a positional sensitivity of around 1 mm, using methods successfully developed in a BBSRC- funded study of fish muscle. We now plan to apply these same methods to solve the full unit cell structure in relaxed insect flight muscle. We will further extend this study to solving the structure of rigor insect muscle which is also crystalline and will provide direct information on the actin-myosin interface and on the conformation and flexibility of the myosin heads in different states.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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