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Leydig cell differentiation and development
Reference
S10777
Principal Investigator / Supervisor
Professor Peter O'Shaughnessy
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Department of Veterinary Pre-clinical St
Funding type
Research
Value (£)
231,951
Status
Completed
Type
Research Grant
Start date
05/06/1999
End date
05/06/2002
Duration
36 months
Abstract
The aims of this project are to identify factors regulating (a) Leydig cell number and (b) development of the adult Leydig cell phenotype. This second aim depends on availability of suitable markers for fetal and adult Leydig cells. We have identified one such marker and propose characterising gene expression in the two Leydig cell populations by use of diagnostic sequencing tags to identify further markers. Mutant and knockout mouse strains will be used to identify factors regulating Leydig cell number and generation of the adult Leydig cell phenotype. Preliminary data suggest that androgens may be crucially involved in this latter process.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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