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Structural and functional properties of insect voltage-gated sodium channels and their interactions with pyrethroids
Reference
S10233
Principal Investigator / Supervisor
Professor Peter Norman Russell Usherwood
Co-Investigators /
Co-Supervisors
Dr Ian Duce
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
188,234
Status
Completed
Type
Research Grant
Start date
01/11/1998
End date
01/11/2001
Duration
36 months
Abstract
A collaborative programme of research with Professor A. Devonshire and Dr M Williamson, IACR Rothamsted will investigate the action of type-I and type-II pyrethroids on Drosophila wild-type and mutant para Na+ channels. Mutational studies and complementary expression studies in the SF21 insect cell line (ligand binding) and Xenopus oocytes (voltage and patch clamping) will further define which Na+ channel mutations are responsible for resistance to pyrethroids. Parallel studies with subunits of rat brain Na+ channels will identify the molecular determinants for the relatively low mammalian toxicity of pyrethroids. The above studies will be guided, in part, by data derived from analyses of Na+ channel sequences in wild-type and pyrethroid-resistant insect pests of agricultural importance.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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