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Developmental changes in ion channel expression occurring during maturation of swimming motor pattern in Xenopus
Reference
S10204
Principal Investigator / Supervisor
Professor Nicholas Dale
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
162,651
Status
Completed
Type
Research Grant
Start date
01/12/1998
End date
24/04/2002
Duration
41 months
Abstract
Neural circuits for motor pattern generation arise early in, and are modified during, development. However the mechanisms underlying this maturation remain unclear. The Xenopus embryo and larva constitute an excellent system for studying how developmental modification of the properties of spinal neurons cause functional changes in motor output. We shall study how ion channel expression in neurons from the spinal motor network in Xenopus changes during late embryonic and early larval development; characterise the voltage-gated currents present in the larvae; study the developing dendritic structure and channel distribution between soma and dendrites in larval neurons; generate realistic computational models of larval neurons; and study the triggering mechanisms that change channel expression during development from embryo to larva.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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