Award details

Isolation and characterisation of circadian clock genes from the mouse

Reference	S10158
Principal Investigator / Supervisor	Professor Russell Foster
Co-Investigators / Co-Supervisors	Professor Malcolm von Schantz
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	62,744
Status	Completed
Type	Research Grant
Start date	01/12/1998
End date	01/12/2001
Duration	36 months

Abstract

Endogenous circadian clocks are virtually ubiquitous among living organisms and have a profound influence over many aspects of physiology and behaviour. In spite of the recent emergence of three candidate genes, the mechanism for generating circadian rhythmicity in vertebrates is poorly understood. This application proposes to exploit a mouse phenotype (rd) that lacks an ocular clock to isolate novel candidate circadian clock genes. Firstly, radiolabelled cDNA will be used to screen an array of expressed sequence tags. Secondly, a cDNA subtraction library will be produced with wildtype retinal cDNA as a tester and rd cDNA as a driver. After a multistep screening procedure, candidate genes will be investigated for localisation, oscillation and entrainment. (Joint with 90/S10156).

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S10156 Isolation and characterisation of circadian clock genes from the mouse

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