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Regulation by TGF-beta of the in vitro growth and differentiation of a bone marrow-derived homologue of the intestinal mucosal mast cell
Reference
S10130
Principal Investigator / Supervisor
Professor Hugh Miller
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Veterinary Clinical Studies
Funding type
Research
Value (£)
206,031
Status
Completed
Type
Research Grant
Start date
15/02/1999
End date
14/02/2002
Duration
36 months
Abstract
Intestinal mucosal mast cells (IMMC) are morphologically and functionally distinct from mast cells in other tissues. They are recruited to the gut in large numbers and secrete granule chymases systemically and into the gut lumen during nematode infection. IMMC contribute to the immunological rejection of nematodes and are highly regulated by TH2 cells. We hypothesise that, in conjunction with T cell- derived cytokines and stem cell factor (SCF), the cytokine TGF-beta1 plays a crucial role in driving the early differentiation of mouse bone marrow cells into homologues of IMMC which express and secrete abundant quantities of the IMMC granule- specific beta-chymase mouse mast cell protease-1 (mMCP-1). We will investigate the role of TGF-beta1 in regulating both the early differentiation of IMMC-like mouse bone marrow-derived mast cells (mBMMC), and the expression and secretion of inflammatory mediators.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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