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Involvement of WC1-gamma-delta T cells in the immune response of cattle to Mycobacterium bovis

Reference	S09909
Principal Investigator / Supervisor	Dr John Pollock
Co-Investigators / Co-Supervisors	Professor Christopher Howard
Institution	Queen's University of Belfast
Department	Agriculture & Environmental Science
Funding type	Research
Value (£)	160,183
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	01/01/2002
Duration	36 months

Abstract

The investigation is of the function of WC1+gamma-delta T cells and how they are involved in the development of the immune responses to Mycobacterium bovis. This exploits an opportunity to investigate infection in the natural host and the role of the WC1 cells, a subpopulation of gamma-delta T cells not evident in species other than ungulates. There is a lack of understanding of the immune response that develops in cattle and murine models do not effectively mimic the natural disease. WC1-gamma- delta T cells accumulate in lesions and increase in the circulation after infection. The study will determine the role of WC1 T cells in vivo by depletion with monoclonal antibody; the effect of M. bovis infection of antigen presenting cells on their function; MHC restriction of the WC1 response; how presentation of antigen by WC1 cells affects CD4 T cell responses; and which antigens are recognised by WC1 cells.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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