Award details

Molecular neurobiology of the mammalian circadian clock

Reference	S09882
Principal Investigator / Supervisor	Dr Michael Hastings
Co-Investigators / Co-Supervisors	Professor Charalambos Kyriacou
Institution	University of Cambridge
Department	Physiology Development and Neuroscience
Funding type	Research
Value (£)	345,889
Status	Completed
Type	Research Grant
Start date	01/02/1999
End date	01/06/2002
Duration	40 months

Abstract

This project will build on a previous pilot study to characterise the molecular neurobiology of the mammalian circadian clock. First, we will use differential display to isolate and characterise novel cycling transcripts in the hypothalamus and retina. Second, we will examine the factors which regulate the expression of these, and other recently identified mammalian clock genes, in vivo. Third, we shall obtain full sequence information on transcripts which exhibit behaviour of putative clock genes. Finally, we will test the role of these genes in vivo by examining the consequences of transient transgenic manipulation of their expression using virally mediated gene transfer in the hypothalamus.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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