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An examination of virus and host cell protein interactions which effect the molecular pathogenesis of paramyxovirus infections
Reference
S09817
Principal Investigator / Supervisor
Professor Richard Randall
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
139,088
Status
Completed
Type
Research Grant
Start date
01/01/1999
End date
01/01/2002
Duration
36 months
Abstract
The aims of this project are to further understand the molecular pathogenesis of paramyxovirus infections, using SV5 as a model virus, and to identify those host cell constraints which prevent paramyxoviruses from crossing species barriers. This will involve using reverse genetics to construct recombinant viruses with selected mutations and examining the pathogenesis of these viruses in a murine model system. An examination will also be made of how SV5 interacts with interferon induced cellular defence mechanisms. The functional significance of the molecular interaction of the V protein of SV5 with the host cell UV-DNA damage binding protein will be examined, as will the effect of V on NF-kB function, cell gene expression and apoptosis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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