Award details

Characterisation and action of spermatid maturation factor in Ixodidae

Reference	S09657
Principal Investigator / Supervisor	Professor Huw Rees
Co-Investigators / Co-Supervisors	Dr Philip Turner
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	180,764
Status	Completed
Type	Research Grant
Start date	23/03/1999
End date	06/08/2003
Duration	52 months

Abstract

The final stage of sperm development in hard ticks is triggered by a small protein(s) from the male accessory gland, the sperm maturation factor (SMF). The overall objective of the project is to characterise SMF and its involvement in initiating the final stage of sperm maturation in the tick, Amblyomma hebraeum. The specific aims are: (i) to isolate SMF, to undertake limited amino acid sequencing of the protein, and to produce anti- SMF antiserum, (ii) to isolate and sequence the full-length cDNA encoding SMF to provide the primary structure of the protein, and to produce recombinant SMF for structure determination and studies on its action, and (iii) to elucidate the site(s) and developmental profile of expression of SMF, and to correlate the expression pattern with physiological/developmental events.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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