Award details

Interleukin 1beta: a comparative study of gene structure and function

Reference	S09641
Principal Investigator / Supervisor	Professor Chris Secombes
Co-Investigators / Co-Supervisors
Institution	University of Aberdeen
Department	Inst of Biological and Environmental Sci
Funding type	Research
Value (£)	139,368
Status	Completed
Type	Research Grant
Start date	15/09/1998
End date	15/09/2001
Duration	36 months

Abstract

The objective of this project is to study the molecular and functional evolution of the cytokine interleukin 1 beta. We will (1) analyse the predicted protein structure of IL1 beta in representative vertebrate groups (namely fish, amphibians and birds) obtained by screening cDNA with oligonucleotides based on an identified universal region (fish compared with mammals) seen in the trout sequence recently obtained in our laboratory. (2) look for further homology in the lower vertebrate sequences that may allow screening of protochordates or other invertebrates with additional probes. (3) produce a fish, amphibian and chicken recombinant IL1 beta based on these gene sequences, to allow testing of biological activity and (4) analyse the IL1 beta gene structure in the above vertebrate groups using genomic libraries.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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