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Homing of lymphocytes to the gut associated lymphatic tissue during intestinal helminth infection.

Reference	S09572
Principal Investigator / Supervisor	Professor Kathryn Else
Co-Investigators / Co-Supervisors	Professor Richard Grencis
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	115,470
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	15/11/2000
Duration	25 months

Abstract

The beta 7 family of integrins is critical in the migration of lymphocytes to gut associated lymphatic tissue, with alpha 4 beta 7 directing lymphocytes to the Peyer's patches via its interaction with MAdCAM-1 and alpha E beta 7 mediating adhesion of intraepithelial lymphocytes to E-cadherin positive epithelial cells. Most of these studies have been performed in vitro in the absence of antigen, with little information available on homing patterns of cells in vivo in the presence of antigen. We will investigate the homing patterns of lymphocytes to the gut associated lymphatic tissue, in vivo in the presence of antigen using two models of intestinal helminth infection. A variety of complementary approaches will be employed including the use of beta 7 integrin knockout mice. Our study will address two fundamental questions: (a) in resistance to intestinal nematode parasites how important is the migration of antigen-specific cells from the blood to the gut? and (b) what are the homing patterns of naive and primed T cells in situations of chronic antigen stimulation and inflammation?

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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