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Functional analysis of a novel vertebrate photopigment
Reference
S09568
Principal Investigator / Supervisor
Professor Russell Foster
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
140,932
Status
Completed
Type
Research Grant
Start date
01/05/1998
End date
01/05/2001
Duration
36 months
Abstract
We have recently discovered a novel opsin family in the vertebrates that we have designated the vertebrate ancient (VA) opsin family 1. This opsin has several unique features that distinguish it from all other vertebrate opsins. Our ultimate aim is to define the function of VA opsin, and resolve the issue of what physiological and behavioural activities this photopigment is regulating. We propose an initial molecular approach that will: (a) localise VA opsin to specific retinal, pineal and possibly other CNS cell types; (b) determine the spectral absorbance of VA opsin photopigment; (c) determine VA opsin/G-protein transducin interactions. The results from these experiments will be used to guide future physiological and behavioural studies that will place VA opsin photopigments into a functional context.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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