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Molecular characterisation and developmental expression of enzymes mediating yolk processing
Reference
S09513
Principal Investigator / Supervisor
Professor Charles Tyler
Co-Investigators /
Co-Supervisors
Professor John Sumpter
Institution
University of Exeter
Department
Biosciences
Funding type
Research
Value (£)
148,754
Status
Completed
Type
Research Grant
Start date
08/06/1998
End date
16/05/2003
Duration
59 months
Abstract
In egg-laying vertebrates, all the nutrients for early embryonic development have to be sequestered and stored in the developing oocyte. The enzymes mediating yolk storage and yolk mobilisation are vital for the production of a viable offspring, yet we know very little about these systems, and almost nothing at the molecular level. We intend to clone and sequence some of the cathepsin enzymes and lipoprotein lipase that play key roles in yolk metabolism in oogenesis/embryogenesis in the rainbow trout. The molecular probes developed will be used to examine the developmental expression of these enzymes throughout oogenesis and early embryogenesis. In parallel, we propose to analyse the functional activities associated with these enzyme and determine the course of yolk reserve catabolism throughout oogenesis and early embryogenesis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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