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Mechanisms of gammaherpesvirus induced pathology in the lymphoid system
Reference
S09323
Principal Investigator / Supervisor
Professor Anthony Nash
Co-Investigators /
Co-Supervisors
Professor Bernadette Dutia
Institution
University of Edinburgh
Department
Veterinary Pathology
Funding type
Research
Value (£)
172,096
Status
Completed
Type
Research Grant
Start date
01/05/1998
End date
01/05/2001
Duration
36 months
Abstract
MHV-68 is a B cell tropic murine gammaherpesvirus which provides an excellent model system to study the lymphoproliferative disorders associated with gammaherpesvirus infections. We have identified two pathological processes occurring during MHV-68 infection: splenomegaly and splenic atrophy. The latter occurs in mice deficient in the IFN- gamma receptor. In order to understand the virological and immunological mechanisms associated with these lymphoid pathologies we will: (1) characterise the cellular and histological changes that occur in the spleens of normal immunocompetent mice (splenomegaly) and mice lacking an interferon-gamma receptor (splenic atrophy); (2) investigate the role of cytokines and cytolytic activity in these processes, and (3) identify the functional role of the ORF1 virus gene product in the widespread changes that occur in mice devoid of the interferon-gamma receptor and in normal mice.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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