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Roles of the VIP family of peptides in circadian rhythm processes
Reference
S09277
Principal Investigator / Supervisor
Professor Hugh Piggins
Co-Investigators /
Co-Supervisors
Professor Clive Coen
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
190,204
Status
Completed
Type
Research Grant
Start date
19/10/1998
End date
19/10/2001
Duration
36 months
Abstract
The circadian pacemaker in mammals is located in the suprachiasmatic nuclei (SCN). Recent evidence indicates that the related peptides VIP and PACAP are (1) differentially present in SCN afferents (from the retina), intraSCN connections and extraSCN efferents and (2) differentially capable of phase-shifting the clock when administered at specific phases of the cycle (VIP can mimic the effects of a light pulse and PACAP those of a dark pulse). We will adopt a multidisciplinary approach involving behaviour, neurophysiology, in situ hybridisation, RT-PCR and transgenic animals to elucidate the distinct roles and sites of action of these peptides in circadian processes and the mechanisms underlying the gating of the phase-specific responses.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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