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Stem cell factor: production and its role in generation of host protective immunity to intestinal nematode parasites
Reference
S09250
Principal Investigator / Supervisor
Professor Richard Grencis
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
188,246
Status
Completed
Type
Research Grant
Start date
23/03/1998
End date
23/03/2001
Duration
36 months
Abstract
Over the last decade studies of protective immunity to infectious agents has largely focused on the role of T helper cell subsets in regulation of responses through the secretion of defined sets of cytokines. Unfortunately, the dominance of the T cell response has been at the expense of investigations of non-T cell components of protective immunity. Recently, we have extended observations of the T cell response indicating an essential role for a non-T cell derived growth factor (Stem Cell Factor, SCF) in the generation of host protective immunity to an intestinal nematode. The present project will test the hypothesis that differences in production of SCF exert a major influence on the protective immune response to helminth infection.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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