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Analysis of the early immunopathological events of sheep paratuberculosis
Reference
S09244
Principal Investigator / Supervisor
Professor John Hopkins
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Veterinary Pathology
Funding type
Research
Value (£)
87,810
Status
Completed
Type
Research Grant
Start date
11/01/1999
End date
11/07/2000
Duration
18 months
Abstract
Paratuberculosis is a chronic intestinal condition of adult ruminants resulting from neonatal infection with Mycobacterium avium subspecies paratuberculosis (Map). The disease is immune-mediated but mechanisms which are protective or permissive in the early stages are undefined. The primary objective of this study will be to establish and optimise a reliable, acute model of Map infection in lambs, and to characterise the associated early, local (Peyer's patches, mesenteric lymph nodes) immunopathological events. Particular emphasis will be given to Th1 versus Th2 modulation and Map/B cell interactions. Correlates will then be sought between immunity and disease development using a variety of intervention strategies including vaccination, nutritional (vitamin D/calcium) modulation and immunosuppression to alter infection/disease susceptibility.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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