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Topographic mapping of principal water diffusivities and perfusion in healthy human brain by magnetic resonance imaging
Reference
S09167
Principal Investigator / Supervisor
Professor Christopher Huang
Co-Investigators /
Co-Supervisors
Dr Thomas Carpenter
,
Professor Laurie Hall
Institution
University of Cambridge
Department
Physiology
Funding type
Research
Value (£)
140,989
Status
Completed
Type
Research Grant
Start date
01/02/1998
End date
01/02/2001
Duration
36 months
Abstract
The project will develop methods to map strategic cerebral parameters to high resolution in healthy human brains. We will determine the three principal water diffusivities and the objective diffusion isotropy and anisotropy indices using diffusion-weighted magnetic resonance imaging (MRI) and the regional cerebral blood flow using magnetically tagged arterial water as freely diffusible tracer. Finally, we will accurately register those parameters onto high-resolution anatomical MR images. This will produce robust and reliable maps of normal cerebral architecture, diffusion and perfusion properties, useful for physiological studies and for the detection and analysis of various cerebral pathologies and conditions, acute and chronic.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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