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Relationship between the tapasin TAP and class I in humans and rats
Reference
S08722
Principal Investigator / Supervisor
Professor John Trowsdale
Co-Investigators /
Co-Supervisors
Dr Geoff Butcher
Institution
University of Cambridge
Department
Pathology
Funding type
Research
Value (£)
183,766
Status
Completed
Type
Research Grant
Start date
01/04/1998
End date
01/04/2001
Duration
36 months
Abstract
The Tapasin molecule forms a bridge between the TAP transporters and MHC class I structures in the endoplasmic reticulum. We recently mapped the Tapasin gene close to the MHC. The linkage of Tapasin, TAP, LMP and class I genes close to each other on the chromosome calls for some regulatory or functional significance. Here we propose to identify polymorphisms in human and rat Tapasin genes and establish their genetic relationships with known TAP and class I variation. The rat model is particularly attractive because of the functional relationships already established between certain rat class I/TAP allele combinations in cis.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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