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Tissue development and differentiation: the adrenocortial model
Reference
S08703
Principal Investigator / Supervisor
Professor Gavin P Vinson
Co-Investigators /
Co-Supervisors
Institution
Queen Mary University of London
Department
Barts and The London School of Medicine
Funding type
Research
Value (£)
179,984
Status
Completed
Type
Research Grant
Start date
05/01/1998
End date
05/01/2001
Duration
36 months
Abstract
The adrenal cortex is an ideal mammalian in vivo model for the study of tissue differentiation. Several components may contribute to the establishment of a developmental polarity in the gland, and compelling evidence now suggests that the tissue renin-angiotensin system has a critical role. We will specifically examine the roles of the RAS and other paracrine morphogens and growth factors, and of specific transcription factors in adrenocortical cellular proliferation and development. Use will be made of a variety of methods, including assays for cell migration and adhesion, short circuit current changes, immunocyto-chemistry and in situ hybridisation, with manipulations that affect adrenocortical zonation and the contributions of intracellular trophic events.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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