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Perirhinal cortex metabotropic glutamate receptors synaptic plasticity and recognition memory

Reference	S08650
Principal Investigator / Supervisor	Professor Malcolm Brown
Co-Investigators / Co-Supervisors	Professor John Aggleton, Professor Zafar Bashir
Institution	University of Bristol
Department	Anatomy
Funding type	Research
Value (£)	184,056
Status	Completed
Type	Research Grant
Start date	01/02/1998
End date	01/02/2001
Duration	36 months

Abstract

The proposed experiments are designed to determine: 1. the role(s) within the perirhinal cortex of metabotropic glutamate (mGlu) receptors; (i) in synaptic transmission, and (ii) in the induction and maintenance of different forms of synaptic plasticity. These experiments will involve making electrophysiological studies of perirhinal cortical slices maintained in vitro, using selective mGlu receptor agonists and antagonists, and transgenically modified mice in which mGlu receptor function has been modified or disabled (`knockouts'). 2. the role(s) of mGlu receptor activation in visual recognition memory through measuring differential immediate early gene expression and recognition memory in mGlu receptor knockout mice. The proposed studies will hence seek correlations between mGlu receptor functions at cellular, systems, and behavioural levels.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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