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Award details
Seasonal regulation of immunity
Reference
S08644
Principal Investigator / Supervisor
Dr Stephen Hopkins
Co-Investigators /
Co-Supervisors
Professor Andrew Loudon
Institution
The University of Manchester
Department
Medical and Human Sciences
Funding type
Research
Value (£)
115,196
Status
Completed
Type
Research Grant
Start date
11/05/1998
End date
18/02/2001
Duration
33 months
Abstract
This proposal aims to identify the influence of photoperiod on immunity and has 2 clear objectives: (1) to identify specific aspects of immune responsiveness which are altered by variation in photoperiod and (2) to define the role of melatonin in this process. This will be undertaken using the seasonally breeding Syrian hamster as a photoperiodic model. Animals maintained on long or short photoperiods, or exposed to melatonin signals of differing duration, will be used to define specific secondary cellular and humoral responses, primary lymphocyte activation and non-specific responses. Cytokine responses will be determined by use of quantitative reverse transcriptase PCR.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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