Award details

Pathogenesis cross-species infectivity and immunogenicity of morbilliviruses

Reference	S08496
Principal Investigator / Supervisor	Professor Bertus Karel Rima
Co-Investigators / Co-Supervisors	Professor Thomas Barrett
Institution	Queen's University of Belfast
Department	Sch of Biological and Food Sciences
Funding type	Research
Value (£)	217,478
Status	Completed
Type	Research Grant
Start date	01/03/1998
End date	30/09/2001
Duration	43 months

Abstract

This proposal seeks to further develop rescue systems for rinderpest and canine distemper virus in order to make mutant viruses which express reporter genes. These will be used to study the pathogenesis of these viruses which is surprisingly poorly defined at present. The effect of defined mutation on the attenuated phenotype of the viruses will also be assessed in animal models and the natural host. We also plan to make chimaeric viruses which will allow a study of barriers to cross-species infectivity. This is an important question, as in the future measles eradication and discontinuation of immunisation or natural infection will make the human population susceptible to infection by other morbilliviruses, especially CDV. Finally we will investigate whether expression of a specific antigen in morbillivirus vectors can change immune responses of short duration into ones which last longer.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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