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Peptide-binding specificities of chicken MHC class II molecules
Reference
S08229
Principal Investigator / Supervisor
Professor Jim Kaufman
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Immunology Compton
Funding type
Research
Value (£)
139,620
Status
Completed
Type
Research Grant
Start date
01/07/1998
End date
01/07/2001
Duration
36 months
Abstract
The aim of this work is to determine the peptide-binding specificities of chicken MHC class II molecules, in order to develop the molecular basis to understand and predict the immune response of chickens with particular MHC haplotypes to pathogens and vaccines. Peptides will be eluted from immunoaffinity-purified class II molecules isolated from chicken cells or from transfectants, and sequences of peptide pools and individual peptides will be determined by chemical degradation and mass spectrometry. The resulting peptide motifs will be used to analyse responses to vaccines for infectious bursal disease (IBDV) and Marek's disease virus (MDV), and then used to predict optimal vaccine-host genotype combinations.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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