Award details

Characterisation and function(s) of Lawsonia intracellularis haemolysis in pathogenesis of Porcine Proliferative Enteropathies

Reference	S08055
Principal Investigator / Supervisor	Professor David Smith
Co-Investigators / Co-Supervisors	Dr Steven McOrist
Institution	University of Edinburgh
Department	Veterinary Pathology
Funding type	Research
Value (£)	192,613
Status	Completed
Type	Research Grant
Start date	01/08/1997
End date	01/10/2000
Duration	38 months

Abstract

Lawsonia intracellularis is a novel bacterium which is the aetiological agent of proliferative enteropathies (PE) of animals, particularly pigs. It is an obligate intracellular pathogen, for which pathogenic mechanisms remain to be defined. Genotypic and phenotypic evidence identifies a haemolysin in this bacterium which has potential roles in pathogenesis. Haemolysin will be cloned and expressed in vitro for mechanistic characterisation and examination of cytotoxic activities in vitro versus cells of epithelial, endothelial and leukocyte/lymphocyte. Recombinant and wild-type and bacteria will be applied for determination of haemolysin function(s) during infection in vitro and in vivo. These examinations represent the first detailed molecular and functional examinations of the pathogenesis of this novel animal pathogen.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search