Award details

Glutathione-s-transferases of veterinary parasitic nematodes as potential targets for drug and vaccine therapy

Reference	S08054
Principal Investigator / Supervisor	Professor Andrew Tait
Co-Investigators / Co-Supervisors	Professor Peter Brophy
Institution	University of Glasgow
Department	Veterinary School
Funding type	Research
Value (£)	199,922
Status	Completed
Type	Research Grant
Start date	01/01/1998
End date	01/05/2001
Duration	40 months

Abstract

Parasitic gastroenteritis has a major economic impact on the sheep industry world wide and is largely controlled by three main classes of anthelmintic. Parasite resistance to treatment is increasing thus warranting the investigation of new control methods. This proposal aims to characterise the glutathione-S-transferases of O. circumcincta and evaluate their potential as targets for chemo and immunotherapy. The project will use a combination of biochemical and molecular techniques to characterise the native enzymes and the genes encoding them as well as expressing the recombinant molecules at high levels so that inhibitor screens and vaccination trials can be undertaken. The rationale for choosing these enzymes as targets for the development of new control methods, is their central role in the immune evasion mechanisms of nematodes mediated via immunosuppression and the detoxification of free radicals generated by the immune response.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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