Award details

Cerebellar cortex and associative learning of motor responses

Reference	S07965
Principal Investigator / Supervisor	Professor Christopher Yeo
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	199,324
Status	Completed
Type	Research Grant
Start date	01/09/1997
End date	01/06/2000
Duration	33 months

Abstract

We will analyse the role of the cerebellum in motor learning. Theoretical models suggest a major role for the cerebellar cortex in motor learning and in vitro studies have revealed that a long term depression (LTD) of efficacy can be induced at some cerebellar cortical synapses. But there has been little evidence to establish a causal relationship between such synaptic plasticity and the behavioural manifestation of motor learning. Using classical conditioning of the rabbit's nictitating membrane/eyeblink response, a simple form of associative learning of a motor response, we will test the hypothesis that motor memories are formed and stored within the cerebellar cortex. These studies will establish whether motor learning is a fundamental operating principle of the cerebellum and will help our wider understanding of the role of the cerebellum in the control of movement.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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