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Characterisation of secreted protein kinases in Trichinella spiralis infective larvae
Reference
S07956
Principal Investigator / Supervisor
Professor Murray Selkirk
Co-Investigators /
Co-Supervisors
Dr Kleoniki Gounaris
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
164,675
Status
Completed
Type
Research Grant
Start date
18/08/1997
End date
17/01/2001
Duration
41 months
Abstract
We propose to purify and biochemically characterise the protein kinases secreted by infective (muscle stage) larvae of the parasitic nematode Trichinella spiralis. Genes encoding the secretory protein kinases will be isolated and the primary structure of the enzymes determined. The dynamics of expression and localisation of parasite-derived kinases in infected rat skeletal muscle will be determined. Potential substrates for the enzymes will be investigated in vitro, and the phosphorylation status of proteins which regulate cell cycle re-entry examined throughout infection in vivo.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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