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Structural characterisation of glycans from parasitic helminths by high sensitivity mass spectrometry
Reference
S07902
Principal Investigator / Supervisor
Professor H Morris
Co-Investigators /
Co-Supervisors
Professor Anne Dell
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
164,574
Status
Completed
Type
Research Grant
Start date
01/04/1997
End date
01/04/2000
Duration
36 months
Abstract
High sensitivity fast atom bombardment, electrospray and laser desorption mass spectrometry will be used to define covalent structures of glycans from two economically important nematodes, Haemonchus contortus, a major sheep pathogen, and bovine lungworm Dictyocaulus viviparus, and from the cestode Echinococcus granulosus, a human and animal parasite. The proposed work will build upon our recent discoveries of potentially highly immunogenic N- and O-glycans in several helminth parasites. We aim to provide rigorous structural data essential for underpinning research addressing the molecular basis of carbohydrate-mediated immune responses in host-parasite interactions.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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